Abstract: Objective: The aim of the study was to explore symptom clusters in patients with chronic stable heart failure.Methods: Symptoms were measured using heart failure-related-symptom items in the Minnesota Heart Failure Quality of Life Scale. Results: The results of exploratory factor analysis showed that two symptom clusters were identified based on the incidences of given symptoms. They were named as physical symptom cluster and emotional symptom cluster, respectively.The Cronbach's α coefficients of each symptom cluster were 0.826 and 0.832. The results showed that age, gender, place of residence, work, educational level, income, smoking history, regular exercise, etiology, duration, CCI and NYHA are influencing factors of physical symptom cluster. Whether living alone, regular exercise, BMI, etiology, duration, CCI, NYHA and medication are influencing factors of emotional symptom cluster. Conclusion: Symptom clusters play a crucial role in symptom management of heart failure patients. The results of the study were helpful to guide health care providers to develop interventions based on the symptom clusters.