Abstract: Objective: To explore the effects of group education basing on social support model on stigma of firstdegree relatives of patients with first-episode schizophrenia. Methods: A total of 150 first-degree relatives of patients with first-episode schizophrenia diagnosed by Shanghai Mental Health Center were recruited. Patients of the control group (n=75) received routine group education, while those of the observation group (n=75) received group education basing on social support model additionally. The effect was assessed using Perceived Devaluation Discrimination Scale (PDD). Results: After intervention, the PDD level of the observation group (28.14±4.72) were lower than that of the control group and the effect in the observation group was significantly better than that of the control group (30.63±5.59). Conclusion: Group education basing on social support model can effectively reduce the level of stigma perception of first-degree relatives of patients with first-episode schizophrenia.