Abstract: The occupational safety of medical staff is a prominent issue for medical institutions. How to effectively reduce the occupational hazards in the work place needs to be explored. Project management combines the project management theory and management method. This paper introduced the effects of the project management in general hospital,including occupational hazards and infection control, occupation musculoskeletal risk factors and ergonomics management,solutions to workplace violence. It is expected to provide information for further studies in this area.