Abstract: Systematic approach of occupational health protection for healthcare workers was advocated and practiced in Chinese pilot hospitals, through the application of the Model of Corporative Initiatives on Systematic Prevention and Control of Occupational Disease (CISCOD Model) in hospitals. Starting from the implementation of the national occupational health standard-Guideline for Prevention and Control for Occupational Exposure Bloodborne Pathogen (code: GBZ/T 213), alongside with further implementation and promotional work of the HealthWISE, the Model of Hospital Initiative on Systematic Occupational Health (HISOH Model) was gradually created and developed. The core principle of HISOH Model is the protection and maintenance of the highest degree of safety, health and well-being of healthcare workers, the purpose of HISOH Model is to establish a safe and healthy working environment and working conditions. This article illustrated the key points of HISOH Model from its theoretical design to good practice, described the core concepts, characteristic, development and future directions of the Model, and summarized the three key development stages of occupational health for healthcare workers and its characteristic in China. With the aim to maximize the mutuality of benefits of healthcare workers, patients and the grand public, as well as to help hospitals who commit to occupational health and well-being of healthcare workers to take the leading role in this filed, the article introduced the national and international network of occupational health protections of healthcare workers, where cooperation opportunities and technical resources are available.