Abstract: Objective: To determine whether medical integration mode improves the quality and safety of handoffs for patient transitioning from the Intensive Care Unit (ICU). Methods: The medical integration mode was applied from July 2015 to December 2016, with a checklist and standardized hand-off procedure. Results: The rate of return to ICU within 48 hours decreased from 1.79% to 0.87% (P<0.05). The incidence of adverse events during transfer decreased from 14.05% to 3.24% (P<0.01). The average time of hand-off was shortened from (18.70±2.62) min to (10.52±2.14) min (P<0.01). The disputes between patients and nurses reduced to none. Conclusion: Medical integration is an accurate, safe, and efficient way to perform handoffs and provide high-quality patient care.