Abstract: Objective: To investigate the effect of film scenes embedded in a Case-Based Learning (CBL) course on developing nursing knowledge, skills and emotion ability of nursing students. Methods: 123 undergraduate nursing students were assigned into control group (n=60) and experimental group (n=63). Regular PBL was applied to control group, while video clips were produced to embed in PBL as cases in experimental group. At the end of the course, the differences of theoretical knowledge, practical skills and emotional abilities of the two groups were compared. Results: The ability of empathy of nursing students in control group was higher than experimental group on baseline, but there were no significant differences between the two groups in humanistic literacy and nurse-patient communication ability. After the intervention, theoretical knowledge, practical skills, empathy ability, humanistic accomplishment and communication abilities of experimental group were more improved than control group (P<0.05). Conclusion: The case scenarios with instructional video clips using in disaster nursing CBL were designed to improve nursing students’ knowledge, skills and emotional ability.