Abstract: The aims of our project were to improve the treatment as well as the physical and mental rehabilitation outcomes of cancer patients, and enhance the development of oncology nursing. After more than one year of preparation and clinical practice of case management in 817 colorectal cancer patients and breast cancer patients, we achieved seamless management of cancer patients, improved patient retention rate, treatment compliance, quality of life, patient satisfaction and hospital resource utilization rate, and reduced the incidence of medical and nursing disputes. Based on the support of a multidisciplinary team, the case management model is an effective way to realize whole course management of cancer patients and fulfill their demands. It can be used as a reference for case management of other cancer patients and in other hospitals.