Abstract: Objective: To explore the effects of cardiopulmonary rehabilitation nursing on cardio-pulmonary function of inpatients with Coronary Artery Bypass Grafting (CABG). Methods: Convenient sampling method was applied. Totally 100 subjects were randomly located into rehabilitation group and control group. Both groups accepted general nursing care. The rehabilitation group also accepted the cardiopulmonary rehabilitation nursing, which included exercise therapy, respiratory training and patient education, with kinesitherapy as the central regimen. Before and after the surgery, the ultrasonic examination and cardiopulmonary exercise testing were conducted to evaluate the patients' cardio-pulmonary function. Results: There were no significant differences between rehabilitation group and control group in cardio-pulmonary function before nursing intervention. After nursing intervention, there was significant differences between the two group in the LVED (P<0.05). The VO2max of rehabilitation group in CPET is statistically higher than the control group (P<0.05). Conclusion: Early phase I cardiopulmonary rehabilitation nursing can improve the cardio-pulmonary function and aerobic endurance on the inpatients after CABG. It is suggested that the cardiopulmonary rehabilitation nursing to be performed in the related nursing practice.