Abstract: Objective: To evaluate the impact of mobile and Internet technology using in case management provided to breast cancer patients after surgery. Methods: 150 patients with breast cancer after modified radical mastectomy from March to August 2016 were recruited. Participants were assigned to a test group that had access to an Internet and mobile phone-based case management program (n=75) or to a control group (n=75) that received regular case management program. Postoperative complications, quality of life and patients' satisfaction of the two groups were compared on baseline, 1 month and 2 months after intervention. Results: At the end of the study period, the test group reported a significantly lower postoperative complication incidence rate. The differences of quality of life (100.40±4.88 vs 96.44±4.01) and patients' satisfaction (12.21±0.86 vs 11.87±1.26) 2 months after intervention of the two groups were statistically significant (P<0.05). Conclusion: Mobile and Internet technology using in case management can reduce postoperative complications, improve the quality of life and patients' satisfaction.