Abstract: Objective: Based on the information platform, using the concept of total quality management and ISO 9000 "process control" for falls prevention, so as to reduce the incidence of falls in hospitalized patients. Methods: Established fall-prevention information platform. Set up four function modules and implemented full-path management of falls prevention. Then, bundles of care and key indexes for process monitor were formulated. Implemented the process control on the bases of macro and micro data , carried out different levels and division of fall-prevention process control, implemented time scale falls-prevention process control and monitored the feedback. Results: After the implementation of informational process control, the rate of inpatient fall decreased significantly (P<0.05), and the rate of implementations of fall-prevention process indexes promoted significantly (P<0.05). Conclusions: Implementation of the informational process control reduce the rate of inpatient fall. It also helps to achieve effective and efficient management to prevent falls, so as to guarantee the safety of patients.