Abstract: Objective: To develop and validate avenous thromboembolism risk management system for inpatients.Methods: A panel of VTE specialized nurses was recruited. Based on literature review and clinical practice, a venous thromboembolism risk management system was developed by focus group interview method. Results: Based on the risk management system, the amount of patients that received VTE risk management increased significantly, and nurses raised the awareness of VTE prevention. Combined with hospital information system, identify VTE high-risk departments, and perform proper nursing strategies. Conclusion: The use of the venous thromboembolism risk management system for inpatients can reduce risk of VTE, and promote nurses' VTE prevention strategies.