Abstract: Objective: To investigate the impact of family care on the medication compliance in HIV/AIDS patients with highly active antiretroviral therapy (HAART). Methods: Totally 112 HIV/AIDS patients receiving free HAART 1-95 months were enrolled in the study. The Family Care Index (APGAR) and Morisky Medication Adherence Scale 8-item version (MMAS-8) were applied to investigate their family care and medication compliance. Results: The score of family care was (7.26±2.75) and the score of medication compliance was (6.94±1.20). The total score of family care, the score of fitness and cooperation degree are positively correlated with medication compliance. Conclusion: Family care is the important factor influencing the medication compliance of HIV/AIDS patients with HAART. To improve the medication compliance of HIV/AIDS patients, we could encourage their family members to accept patients' situation of HIV infection, make decisions about medicine taken together, and enhance their ability to solve related issues.