Abstract: Objective: To evaluate the applicability of six illness-severity scoring systems to assess children with Congenital Heart Diseases (CHD). Methods: Intra-class Correlation Coefficient (ICC) was used to measure the inter-rater reliability. Area under ROC curve and Hosmer-Lemeshow goodness of fit test were used to assess the performance of the instruments. Results: 1 284 children with congenital heart diseases were included. The discriminatory power of the specific score for CHD was better than the others (AUC>0.75). The calibration capability of PRISM III, PIM2, and specific score for CHD were tolerable (P>0.05) . Conclusion: The specific score for CHD is better than non-specific instruments for the evaluation of children with CHD.