Abstract: Objective: To analyze the clinical effect of curvilinear supine position on preventing intra-operative pressure ulcers in surgical patients. Methods: The patients were randomly divided into experimental group (50 cases) and control group (51 cases). The patients in experimental group were given the curvilinear supine position and the patients in control group accepted traditional supine position. The incidence of pressure ulcer, the peek pressure of the high-pressure areas, patients′ comfort and doctors′ satisfaction were compared between the two groups. Results:①After positioning, the peek pressures of occipital, caudal, and heel of experimental group were much lower than those of the control group (P<0.05). The pressure decrease of the shoulder blade was not obvious. But, the pressure of the lower leg in the experimental group was higher than control group (P<0.05).②The percentage of patients feeling comfortable with the position in the experimental group was higher than that in the control group (P<0.01). ③The pressure decreases on the sacral and heel persistently of the experimental group with prolonged operation time (P<0.01).④The incidence of intra-operative pressure ulcer immediately after surgery in experimental group was zero, much lower that of the control group (9 cases of stage I pressure ulcer) (P<0.01), and there were no pressure ulcers occurred in both two groups 24 hours after operation. Conclusion: Curvilinear supine position has a positive effect on lowering the interface pressure through pressure redistribution and continuous decompression to the high-pressure areas of the surgical patients, so as to effectively reduce the incidence of intra-operative pressure ulcers, improve patients′ comfort and the quality of nursing in operation room.