Abstract: Objective: To explore effects of supportive interventions on post-stroke patients in community with disability. Methods: Totally 210 post-stroke patients in community with disability were divided into the intervention group and the control group with 105 cases in each group according to their level of self-dependence. Patients in the control group were given health education, while patients in the intervention group were given supportive interventions which centered on physical rehabilitation and supplemented by psychological interventions and family social interventions. Modified Barthel Index (MBI), Self-rating Depression Scale (SDS), General Self-efficacy Scale (GSES) and Functional Activities Questionnaire (FAQ) were adopted before and after interventions as well as 6 months after interventions to assess recovery conditions of patients in both groups. Results: A statistical significance (P<0.05) could be seen when comparing the main effect of intervention factor through SDS, GSES and FAQ between the two groups. As to the main effect of time factor and the interaction factor of MBI, SDS, GSES and FAQ, a statistical significance (P<0.01) also existed. Conclusion: Supportive interventions can effectively improve activities of daily living (ADL), self-efficacy and social functions of post-stroke patients in community with disability, and relieve their depression.