Abstract: Objective: To explore the relationship between doctor-nurse collaboration, perceived benefits and work engagement among ICU nurses. Methods: Totally 230 nurses were investigated by Nurse-Physician Collaboration Scale (NPCS), Nurses' Occupational Benefit Questionnaire (NOBQ), Work Engagement Questionnaire (UWES-9) and a self-designed demographic questionnaire. The data were collected and analyzed statistically. Results: The total score of NPCS, NOBQ and UWES, respectively, was 90.60±14.48, 133.30±17.11 and 25.47±7.68. There were positive relationship among doctor-nurse cooperation, perceived benefits and work engagement (P<0.05). The ICU doctor-nurse collaboration had significant prediction effect on work engagement (P<0.05) and the perceived career benefit was a mediator in the relationship between doctor-nurse collaboration and work engagement. Conclusions: The doctor-nurse collaboration and perceived benefits have significant influence on nurses' work engagement, so doctor-nurse collaboration should be improved and great importance on perceived benefits should be attached in ICU to improve the nursing service quality.