Abstract: Objective: To evaluate the efficacy and safety of prone position ventilation for patients with Acute Respiratory Distress Syndrome (ARDS). Methods: The studies published in PubMed, Embase, Web of Science, the Cochrane Library, CBM, CNKI, VIP, Wanfang database were analyzed. The meta-analysis was applied using RevMan 5.3 software. Results: A total of 9 randomized controlled studies and 2 359 subjects included were analyzed. Meta-analysis showed the mortality rate was statistically significant [OR=0.60, 95% CI (0.40, 0.90), P=0.01], and the combined effect was statistically significant. The incidence of accidental exhalation, ventilator-associated pneumonia, the incidence of pneumothorax, ICU hospitalization time were not statistically significant. Conclusion: The prone position ventilation can reduce the mortality rate of patients with ARDS.