Abstract: Objective: To analyze the influencing factors of quality of sexual life of patients after radical hysterectomy and their sex-related demands for extended-nursing service. Methods: Patients after radical hysterectomy within 5 years in our hospital were enrolled by convenience sampling method. We investigated their quality of sexual life, the influencing factors, and their sex-related demands for extended-nursing service. Results: The results of a linear regression analysis showed that age, education level, economic status, occupational status, anxiety, depression, postoperative sexual instruction of patients as well as their partners were influencing factors of quality of sexual life, accounted for 80.3%. In terms of the sex-related demands for extended-nursing service, Wechat communication (64.4%), duration>1 year (82.7%), nurses as the main intervention subject (58.1%), sexual knowledge introduction (92.1%), sexual health education (91.1%) had the highest degree of acceptance. Conclusions: Nurses should use modern communication tools to provide extended-nursing service for both patients with a wide range of hysterectomy and their partners, in order to obtain a higher degree of acceptance and intervention effects.