Abstract: Objective: To explore the hope level and its influence factors of patients with HIV/AIDS (PWHA) who received antiretroviral therapy (ART), and provide theoretical basis to improve their quality of life. Methods: Totally 206 PWHA receiving free ART 1~109 months were recruited to the study through convenience sampling. The Herth hope scale was applied to measure the hope level and its influence factors were statistically analyzed by logistic regression analysis. Results: The average score of hope level of the 206 PWHA was (36.2±3.89), and the scores ranked in three dimensions from high to low were as follows: taking positive action (12.48±1.73), having a positive attitude to the present and the future (11.98±1.35), and maintaining positive relationship with others (11.74±1.47). The results of the logistic regression analysis indicated that self-identification of HIV infection, monthly income and HIV transmitted way might be the important influencing factors of the hope level of PWHA receiving ART. Conclusion: The PWHA receiving ART in China have a medium or high level of hope. Assisting them to accept the fact of HIV infection, rationally treat with their sexual behavior and acquire social support, could benefit for increasing their hope level and improve their survival quality of life.