Abstract: Objective: To investigate the level of Self-Perceived Burden and influencing factors in patients after Percutaneous Coronary Intervention. Methods: Totally 383 patients after percutaneous coronary intervention were investigated with the general information questionnaire, the Self-Perceived Burden Scale (SPBS), the medical coping modes questionnaire (MCMQ) and the social disability screening schedule (SDSS). Results: The total score of SPBS was 27.25±6.22. The patients with heavy burden, moderate burdenand minor burden were 2.87%, 22.45% and 63.71% respectively. 10.97% of the patients had no obvious burden. Multiple regression analysis showed that coping styles of resignation, the overall level of social support were main predictors of Self-Perceived Burden in patients after Percutaneous Coronary Intervention (P<0.05). Conclusion: The patients after Percutaneous Coronary Intervention experienced Self-Perceived Burden. Nurses should take proper measures to alleviate the patients' Self-Perceived Burden and improve their quality of life.