Abstract: Objective: To explore the characteristics of the interpersonal relationship of intern nurses in a general hospital. Methods: Totally 278 intern nurses were investigated using convenience sampling method. Interpersonal Comprehensive Diagnostic Scale (ICDS) and Interpersonal Competence Questionnaire (ICQ) were applied to assess interpersonal characteristics of the subjects. Results: There were significant differences in interpersonal distress between the intern nurses with different gender, educational backgrounds and clinical practice durations (P<0.05). There were significant differences in interpersonal competence between the nurses with different gender (P<0.05). The interpersonal distress was negatively correlated with the interpersonal competence (P<0.01). Conclusion: Schools and hospitals should provide interpersonal relationship education for intern nurses.