Abstract: Objective: To investigate the current usage status of disposable venous infusion sets and to provide reference for correct usage of disposable venous infusion sets. Methods: Totally 309 head nurses in 11 tertiary Grade A hospitals and 33 secondary hospitals in Shijiazhuang were recruited and investigated by questionnaires. Results: The usage rate of ordinary venous infusion sets in secondary hospitals was obviously higher than that in tertiary hospitals (P<0.05); while the usage rate of precision infusion sets was much lower than that in tertiary hospitals (P<0.05). The usage rate of precision infusion sets when infusing intralipid, chemotherapeutic drugs and Chinese medicine in secondary hospitals was obviously lower than that in tertiary hospitals (P<0.05). No lucifugal infusion device was used in 40% investigated departments in secondary and tertiary hospitals and only 10% investigated departments used infusion set without DEHP material. The habit and rules to choose infusion sets according to instruction of special drugs in tertiary hospitals were better than those in secondary hospitals but all hospitals were not instructed under special pharmacists. Conclusions: Secondary hospitals and teriary hospitals had different level problems in selecting and using venous infusion sets. The managers should strengthen training and inspection to ensure patients' safety.