Abstract: Objective: To investigate the status and factors influencing competency of hemopurification nurses in tertiary grade A hospitals of Hunan province. Methods: 345 hemopurification nurses from 20 general tertiary Grade A hospitals in Hunan were investigated with a self-reported questionnaire. Results: The standardized score of Nurses' competency was (87.84±9.72), certificated nurses' score (91.05±7.21) was higher than the uncertificated ones' (84.3±10.86).Regression analysis showed that qualification, education background, professional title and specialized working year were factors influencing hemopurification nurses' competency. Conclusions: In Hunan, the level of hemopurification nurses' competency was relatively high, especially the certificated ones'. Furthermore, specialized certificated training was proven to be an effective method to promote nurses' competency. Nurses' teaching and researching abilities need to be further improved.