Abstract: Objective: To explore the application effect of two-way selection of mentorship in the standardized training of new ER nurses. Methods: Establish mentor selection criteria, set up mentors group, based on the "equal and voluntary" principal between the new hires in 2014 and mentors, using two-way selection, through the coordination of the nurse manager, assign a mentor for each new hire. Every mentor will have the opportunity to be the in charge mentor. New hires in 2013 were all assigned to a specific mentor by the leaders rather than two way selection. Results: 2014 new hires demonstrate higher score in basic theory, basic skills, specialist theory, specialist skills, and clinical skills assessment than 2013 group (P<0.05); the rate of teaching satisfaction and learning satisfaction in 2014 were higher than 2013 (P<0.05).Conclusion: The application of two-way selection motivate both teachers and students, motivate instructors to improve the quality of teaching, but also help to increase the sense of belonging among new nurses and make them faster, better adapt the new working environment and become competent at work.