Abstract: Objective: To observe the effect of forced-air warming blanket application timing on patient's temperature and complication during brain tumor surgical operation. Methods: We collected 83 brain tumor surgery cases, and then randomly divided into two groups. The treatment group (n=41) was applied ordinary blanket and forced-air warming blanket immediately after the patients were sent into the operating theatre. The patients in the control group (n=42) were given the ordinary blanket when they were into the operating theatre, but given the forced-air warming blanket only when the narcotic induction started. We examined and compared two groups of patients on perioperative body temperature, intraoperative blood loss, postoperative incidence of chills,awakening agitation rate, anesthesia duration, incision infection risk. Results: The patients' body temperatures in the treatment group were higher than the entries when compared at the watching points: the induction, 1.5hour, end of anesthesia respectively. The temperature difference had statistical significance (P<0.05). The patients' body temperatures in the control group were statistically significantly lower than the entries at each watching point except the end of anesthesia (P<0.05). The temperatures in the treatment group from anesthesia induction to the end were higher than the parts in the control group with statistical significance (P<0.001). The incidence of awaken chills, agitation and anesthesia duration was statistically significantly lower in the treatment group than in the control group (P<0.05). Conclusion: This study suggests that forced-air warming blanket should be applied to patients immediately when they enter into operating theatre before brain tumor surgery starts.