Abstract: Objective: To explore the relationship between psychological empowerment and turnover intention, and accomplish the Structural Equation Model. Methods: The convenience sampling method was used to in this study. The psychological empowerment scale, psychological capital scale and turnover intention scale were used to investigate 507 ICU nurses from 5 hospitals. SPSS 13.0 and Amos 17.0 software were used to analyze the date. Results: The scores of psychological empowerment, psychological capital were different among nurses with different nursing years, education level, and income level (P<0.05). And turnover intention scores of nurses with different nursing years and income level were different (P<0.05).Structural Equation Model showed that psychological empowerment had a direct effect (λ2=0.47, P<0.001) on psychological capital. Psychological capital had a direct effect on turnover intention (λ2=-0.62, P<0.001).Psychological empowerment had a direct effect (λ1=-0.81, P<0.001) and indirect effect (λ2=-0.29, P<0.001) through psychological capital which explained 21.28% of the variance of turnover intention. Conclusion:Psychological capital has an effect on ICU nurses' turnover intention. The administrator should use appropriate intervention to increase nurses' psychological capital, so as to improve psychological empowerment to deal with turnover intention.