Abstract: Objective: To discuss the ways and methods of building health service system for stroke patients based on the APP information system, and to expand the application of the system. Methods: The preparation phase was a survey on the demand of stroke patients who were discharged to understand their needs so as to lay a foundation for further research.The preliminary use phase was to update and debug the software due to problems revealed by the first-time online use,namely, too much words and unstable factors. The implementation phase was to comb the complete operation process and update it online to provide convenience for patients. Results: The use of the APP preliminarily realized the seamless docking of in-hospital model and in-home model. Personalized nursing care plans and online consulting services provided professional security assurance for specialized continued health services of patients and effectively relieved patients’ confuse when they were at home. Conclusion: The development of "Doctor and Nurse" APP software preliminarily realized the health service system in which medical care was closely linked to nursing care. Besides, the software could facilitate effective management of patients and solve the problems of stroke patients from multiple perspectives.