Abstract: Objective: To explore the structure of Adverse Events Risk Perception Scale and to test its reliability and validity among clinical nurses. Methods: The draft questionnaire was designed by semi-structure interview and open questionnaire survey, and then revised through Delphi Method and a preliminary test. The reliability and validity of the scale were tested among 917 nurses in Taian city. Data were analyzed by SPSS 19.0 software and AMOS 17.0 software.Results: A scale with three factors and 20 items was identified by using item analysis and exploratory factor analysis. These three factors could explain 60.374% of the variance. The overall content Validity Index (CVI) was 0.91, while the CVI for each item was ranged from 0.71 to 1.00. The confirmatory factor analysis revealed a good fit of the model to the data based on various fit indices (χ2/df=2.427, GFI=0.936, AGFI=0.917, RMSEA=0.049, NFI=0.915, CFI=0.948, IFI=0.948).Exploratory factor analysis and confirmatory factor analysis revealed that the the three dimensions of adverse events risk perception included patient care risk, system process risk, and nurse operation risk. The Cronbach's α coefficient of the scale was 0.939 and the Cronbach's α coefficient of each factor was all above 0.7. The correlations of the scores between each item and the total scale were ranged from 0.46 to 0.77 (P<0.01). Conclusion: The multi-dimensional structure of adverse events risk perception indicates the characteristics of this nursing service. The Adverse Events Risk Perception Scale is reliable and valid, and can be used to measure adverse events risk perception among clinical nurses.