Abstract: Objective: To evaluate the quality of clinical practice guideline of ostomy care, to analyze the status quo and challenges in the guideline development, and to provide reference for making clinical practice guideline of ostomy care suitable for China. Methods: The databases of CNKI, VIP, WANFANG, CBM, PubMed, ProQuest, Web of Science,and related websites and data of guidelines were searched and the retrieval time was from 2006 to 2015. The published clinical guidelines of ostomy care were recruited and language was limited in Chinese and English. The names, publishing years, organizations, development methods were descriptively analyzed and the quality were assessed by AGREE II.Results: A total of 19 guidelines concerning ostomy care were included from USA, Britain, Canada, Sweden and China.Totally 14 full text guidelines of them had been assessed by AGREE II and they were generally low in quality. The levels of guidelines were level A (4 guidelines), level B (8 guidelines), and level C (2 guidelines). The scores of guidelines according to the domains of AGREE II decreased from "scope and purpose" (76.59%), "clarity of presentations" (74.01%),"participants" (66.67%), "rigour of development" (51.93%), "applicability" (46.73%), and "editorial independence" (37.50%).Conclusion: The guidelines of the ostomy care should be improved in "rigour of development", "applicability" and "editorial independence" in future. Conflicts of interest should be addressed. Guidelines are recommended to be developed based on evidence and to use the best evidence. There is still no local evidence-based guideline of the ostomy care in China. So it is urgent to develop evidence-based guideline that is suitable for Chinese condition while utilizing international experiences.