Abstract: Using wireless network technology, mobile technology, Internet of things technology, and bar code technology,etc., we have constructed a new closed loop management of clinical nursing. Mobile nursing information system, infant positioning system, disinfection and supply room tracing system have been applied in the business process of holistic nursing. Meeting the tracking management requirements from the doctor's advice to the implementation of the whole treatment process, the critical care and nursing management. The clinical error rate has been significantly decreased, and the work efficiency has been greatly improved.The quality of clinical care has been improved.