Abstract: Objective: To evaluate follow-up compliance of patients with CKD stage 3-5 in the nutrition clinic, and explore its related factors. Methods: The data of 468 patients with CKD stage 3-5 who got nutrition files created from January 2007 to December 2012 were retrospectively analyzed. Logistic regression was used to analyze the influencing factors of follow-up compliance. Patients' demographic data, family support, baseline renal function and serum albumin level were all included in the analysis. At the same time, the subjective reasons of poor adherence were explored. Results: There were 213 cases that still got follow-up at present. Their data were included in this analysis. Their average follow-up time was (26.85±22.37) months,average age (47.16±13.79), 64 cases (30.05%) had regular follow-up. The Logistic regression analysis showed that family support(OR=2.448, P<0.001), eGFR (OR=0.638, P=0.038), Alb (OR=0.932, P=0.043) were influencing factors of follow-up compliance.Family support had positive correlation with the follow-up compliance. While eGFR and Alb level had negative correlation with the compliance. Eight themes were obtained after interviewing with the patients with poor compliance, and it was found that those patients had not recognized the importance of long-term nutrition management yet. Conclusion: The follow-up compliances of patients with CKD stage 3-5 in the nutrition clinic need to be improved. Nursing education of patient's family should be strengthened to increase their consciousness of the diet nutrition monitoring and management. Hierarchical management according to patients' kidney function and nutrition level should be implemented to prevent malnutrition effectively.