Abstract: Objective: To compare the effects of the Action-oriented Teaching in secondary vocational medical nursing teaching with the traditional teaching model. Methods: By analyzing and comparing the degree of nursing students to master the theoretical knowledge, medical nursing practice skills, case analysis and the nurse qualification mock exam scores to determine the effects of the new teaching model. Results: Action-oriented Teaching method can improve the secondary vocational nursing students' practical operation ability, case analysis ability, communication ability and nursing comprehensive vocational ability. It can improve nursing students' skills in nurse qualification examination to a certain extent.