Abstract: Objective: To investigate the present situation of irrational beliefs and the styles of handling interpersonal conflict in nurses, and explore the effect of irrational beliefs on the styles of handling interpersonal conflict. Methods: Totally 533 nurses were investigated with the Irrational Beliefs Scale (IBS) and the Styles of Handling Interpersonal Conflict Scale (SHICS). The Pearson correlation analysis and multiple linear stepwise regression analysis were used to explore the influence of irrational beliefs on the styles of handling interpersonal conflict in nurses. Results: The average total score of IBS was 2.44±0.67, while the scores of different dimensions were as follows: low frustration tolerance 2.82±0.70, general comments 1.78±0.57, absolute requirements 2.66±0.73, respectively. The average scores of the dimensions in SHICS were integrating 3.46±0.55,avoiding 3.75±0.67, obliging 3.13±0.50, and dominating 3.02±0.44, respectively. The score of integrating was negatively correlated to the low frustration tolerance, general comments, absolute requirements and the total score of irrational beliefs (P<0.05). The scores of avoiding,obliging and dominating were positively correlated to the low frustration tolerance, general comments, absolute requirements and the total score of irrational beliefs (P<0.05). Multiple linear stepwise regression analysis shew that the low frustration tolerance,general comments, absolute requirements were the influencing factors of the styles of handling interpersonal conflict in nurses.Conclusion: The main forms of irrational beliefs and the styles of handling interpersonal conflict in nurses were low frustration tolerance and avoiding, the irrational beliefs was influencing factor of the styles of handling interpersonal conflict in nurses.