Abstract: Objective: To explore the effects of the multidisciplinary-team management model on the incidence of Chemotherapy-Induced Nausea and Vomiting (CINV), chemotherapeutic compliance and satisfaction degree in patients with breast cancer. Methods: Totally 294 breast cancer patients were enrolled as the control group from May to July in 2016 and received regular management, while 301 patients with breast cancer were enrolled as the observation group from August to October 2016, and the multidisciplinary-team management model for CINV was implemented. The incidence of CINV, the compliance of chemotherapy and the patients' satisfaction were compared between the two groups. Results: Both the satisfaction degree and chemotherapeutic compliance of the observation group were higher than those of the control group, while the incidence of CINV was lower than that of the control group (P<0.05). Conclusion: The multidisciplinary-team CINV management model may significantly reduce the incidence of CINV in patients with breast cancer; improve patients' satisfaction and improve patients' compliance with chemotherapy.