Abstract: This research aimed to summarize the evidence-based practice of wound care in a patient with Leukocytoclastic Vasculitis. We clarified main problems of this patient, and searched 9 databases both domestic and abroad, including CNKI, Wanfang Data, SinoMed, PubMed, Cochrane Library, MEDLINE, EBSCO, SCI and National Guideline Clearinghouse. After searching for related literatures and evaluating the level of each evidence summarized from these literatures, the best clinical evidence of wound care for such a patient was determined. The patient was then cared combing the actual situation with the best clinical evidence summarized, and 50 days later the wound healed completely.