Abstract: Objective: To evaluate the anti-infection effects of chlorhexidine and silver sulfadiazine central venous catheters. Methods: The Cochrane Central Register of Controlled Trials, PubMed, Web of Science, EMBASE, CINAHL, CBMdisc, CNKI, Wan Fang database, VIP database and Randomized controlled trials registered websites were searched to collect randomized controlled trials (RCTs) which compared the anti-infection effects between chlorhexidine and silver sulfadiazine central venous catheters and common catheters. Two researchers conducted the data extraction and quality assessment independently, and RevMan 5.2 software was used to analyze the data. Results: Thirty-two RCTs involving 7 765 catheters were included. The results of meta-analyses showed that chlorhexidine and silver sulfadiazine central venous catheters could decrease the catheter-related blood stream infection [RR=0.57, 95%CI (0.51, 0.64), P<0.001] and catheter colonization [RR=0.57, 95%CI (0.51, 0.64), P<0.001] compared with common catheters. Conclusion: Current evidence suggests that chlorhexidine and silver sulfadiazine central venous catheter is effective for prevention of central venous catheter-related blood stream infection and it's suitable for all types of patients. Due to the limitations of the included studies, the quality of the evidence is moderate based on GRADE.