Abstract: Objective: To explore the effects of resistance exercise on Intradialytic Hypotension episodes, nursing intervention times and pre-dialysis blood pressure. Methods: Totally 77 patients with frequent Intradialytic Hypotension from 2 hemodialysis centers were recruited and divided randomly into the intervention group (n=39) and the control group (n=38). The patients in the intervention group were guided to do resistance exercise 3 times per week for 12 weeks besides the routine care, while the patients in the control group received the routine care. The data were collected from August 2015 to March 2016. We collected the data of the two groups' Intradialytic Hypotension episodes, nursing intervention times and pre-dialysis blood pressure before and during intervention. Results: The results showed that the Intradialytic Hypotension episodes and nursing intervention times in the intervention group were significantly less than those in the control group (P<0.05). After 12-week resistance exercise, patients' diastolic pressure decreased and their systolic pressure were stable before hemodialysis . Conclusion: Resistance exercise is effective for the hemodialysis patients with frequent Intradialytic Hypotension to reduce Intradialytic Hypotension episodes, reduce the related nursing intervention times, and to improve blood pressure.