Abstract: Objective: To investigate the influencing factors of the level of hope and its associations with the social support among family caregivers of patients with advanced cancer. Methods: A convenient sample of advanced cancer patients and their family caregivers from five tertiary level first class hospitals in Xi'an were selected. The hope level and social support of family caregivers of advanced cancer patients were investigated with Herth Hope Index and Social Support Rating Scale, and self-designed questionnaire was used to investigate the general, disease and care related conditions of advanced cancer patients and their caregivers. Results: The hope level score of family caregivers of advanced cancer patient was 36.57±4.65, which was a medium to high level; the total score of social support was 37.27±7.38, and it was higher than the Chinese norm (P<0.01); the hope level was positively correlated with social support (r=0.412). Multiple regression analysis showed that the influencing factors of level of hope in caregivers were caregiver support utilization, evaluated physical condition of the patient by caregiver, objective and subjective support, the total household monthly income and age. Conclusion: The medical workers should pay more attention to caregivers of cared patient with poor condition in two weeks, lack of social support, older and economic difficulties and provide knowledge and care support for them to improve their level of hope.