Abstract: Objective: To investigate the level and influencing factors of Self-Perceived Burden (SPB) in elderly patients with chronic non-communicable diseases (chronic disease). Methods: A convenience sample of 1056 elderly patients with chronic diseases and their main caregivers from six centers in Sichuan province were investigated with the self-made patients' general information questionnaire, Self-perceived Burden Scale (SPBS), Barthel Index (BI), FRAIL Scale, Simple Nutritional Evaluation Method (MNA-SF), Geriatric Depression Scale (GDS-15), Zarit caregiver burden interview (ZBI). Results: The score of SPBS of elderly patients with chronic disease was (24.62±7.06), which was at mild to moderate level. The influence factors of SPB were the score of Barthel Index, the place of residence, depression, self-rated health, and gender. Conclusion: The elderly patients with common chronic diseases experience of mild to moderate levels of SPB, we should be aimed at the main influence factors of SPB and take positive measures to alleviate their SPB.