Abstract: Objective: To identify the latent profiles of decision fatigue in Colorectal Cancer patients with enterostomy and explore their influencing factors, so as to provide a basis for developing targeted management strategies. Methods: Using a convenience sampling method, 269 Colorectal Cancer patients with enterostomy from the stoma outpatient clinics of two tertiary hospitals in Jiangsu province were recruited from January 2023 to May 2025. Data were collected using a general information questionnaire, the Decision Fatigue Scale, the Self-Perceived Burden Scale, the Social Support Rating Scale, and the Hospital Anxiety and Depression Scale. Latent profile analysis was used to identify distinct subgroups of decision fatigue, and multivariate Logistic regression analysis was applied to explore the influencing factors. Results: Decision fatigue in Colorectal Cancer patients with enterostomy was categorized into three latent profiles: the "low decision fatigue-lack of confidence"(17.8%), the "moderate decision fatigue-cognitive blockage"(38.7%), and the "high decision fatigue-decision avoidance" (43.5%). Gender, age, stoma duration, self-perceived burden, anxiety, depression, and social support were identified as significant influencing factors (P<0.05). Conclusion: Decision fatigue among Colorectal Cancer patients with enterostomy exhibits population heterogeneity and is influenced by multiple factors. Healthcare staff should identify the specific profiles early and implement stratified intervention strategies to precisely alleviate patients' decision-making burden.

Key words: Colorectal Cancer; enterostomy; decision fatigue; latent profile analysis; influencing factor