Abstract: Objective: To extract and summarize the evidence on nursing care for Artificial Liver Plasma Exchange (ALPE) in patients with liver failure, providing a reference for clinical nursing practice. Methods: Domestic and international clinical decision support systems, relevant guideline websites, nursing-related professional association websites, government websites and databases were systematically searched for evidence including clinical decisions, standards, guidelines, expert consensus and systematic reviews related to ALPE, and the retrieval period was from the inception of databases to December 31, 2024. Researchers conducted quality assessment and data extraction on the included literature, and extracted and integrated the evidence according to the principles of evidence synthesis. Results: A total of 17 articles were included, comprising 2 clinical decision documents, 2 standards, 5 guidelines, 4 expert consensus and 4 systematic reviews. Twenty-eight items of evidence were synthesized into the following 6 domains: preparation for plasma exchange, selection, volume, and storage of replacement fluids, application of anticoagulants, equipment monitoring, prevention and management of complications, and off-machine management. Conclusion: The evidence summarized in this study for ALPE nursing care in patients with liver failure is scientific and practical, and can provide a reference for nursing practice.

Key words: liver failure; Artificial Liver Plasma Exchange; nursing care; evidence summary; evidence-based nursing