Abstract: Objective: To evaluate the effect of eCASH concept on sedation and analgesia management in patients with mechanical ventilation in ICU. Methods: From June 2016 to May 2017, 90 patients with mechanical ventilation who required sedation and analgesia management were selected and divided into two groups (45 cases in the control group, 45 cases in the intervention group) according to their admission order. Patients in the control group were given routine sedative and analgesia management, while patients in the intervention group received sedative and analgesia management according to eCASH concept. Results: The mechanical ventilation time of the intervention group was shorter than that of the control group (t=-3.685, P=0.001). ICU hospitalization time of the intervention group were less than that of the control group (t=-3.397, P=0.001). The rate of successful extubation of the intervention group was higher than that of the control group (χ2=4.731, P=0.030). The rate of death/abandonment in hospital of the intervention group was lower than that of the control group (χ2=5.404, P=0.020). Conclusion: Patients could acquire better recovery and improved quality of life by introducing eCASH concept into sedation and analgesia management of patients with mechanical ventilation in ICU.