Abstract: Objective: To explore the effect of multidisciplinary treatment in the patient with severe trauma combined with wound infection. Method: The multi-disciplinary team included doctors and nurses from ICU, thoracic surgery, orthopedics, plastic surgery, nutrition department, anesthesiology department and wound care clinic. The nutritional support, sedative analgesia were provided to the patient to maintain the vital sign stable. The wound management included removal of necrotic tissue, controlling of bacterial infection and management of exudate, then the skin graft and dressing. Result: The severe trauma infection wound was healed after surgery with 17-day wound bed preparation. Conclusion: Multidisciplinary team can accelerate the wound bed preparation process and improve the healing of wound.