Abstract: Objective: To evaluate effects of intradialytic exercise (IDE) on dialysis adequacy and sleep quality in patients undergoing maintenance hemodialysis (MHD). Methods: MHD patients consistent with inclusion criteria were randomly divided into the experimental group and the controls group. Patients in the experimental group did IDE individual progressive training with smart sports bike on basis of routine care three times a week. And the control group received routine care for 12 weeks. The dialysis adequacy and sleep quality of two groups before and after intervention was observed and compared. Results: After the intervention, the urea clearance index (KT/V) of the experimental group was higher than that of the control group (P<0.05). The score of sleep quality of the experimental group was lower than that in the control group (P <0.05). Conclusion: IDE can improve the dialysis adequacy and sleep quality in MHD patients.