Abstract: Objective: To evaluate the effectiveness and safety of early active mobilization in patients with mechanical ventilation in Intensive Care Unit. Methods: The following databases such as Cochrane Library, PubMed, Web of Science, CNKI, CBM and WanFang Data electronically for Randomized Controlled Trials (RCT) were searched, and other sources as supplement was also retrieved. The quality evaluation and data extraction were carried out by two reviewers, and the Stata/SE 12.0 software was used for Meta analysis. Results: Totally 11 RCTs, 718 patients were enrolled. The results of Meta-analysis showed that the SMD of duration of mechanical ventilation was -0.77 with 95% CI (-1.30, -0.24) and the SMD of the length of stay in ICU was -0.50 with 95% CI (-0.96, -0.04) and the OR of the incidence of Ventilator Associated Pneumonia (VAP) was 0.13 with 95% CI (0.03, 0.62) and the SMD of the incidence of Intensive Care Unit Acquired Weakness (ICU-AW) was 0.36 with 95% CI (0.02, 0.71). The combined effect was statistically significant. The OR of the mortality was 0.89 with 95% CI (0.51~1.55) and not statistically significant. Conclusion: Early active mobilization is effective and safe for patients with mechanical ventilation. It can not only reduce the time of mechanical ventilation and ICU stay, but also can reduce the incidence of VAP and ICU-AW, and thus is worthy of clinical application.