Abstract: Objective: To observe the effect of hospital infection control team in infection control of Multidrug-Resistant Organism (MDRO) in ICU. Methods: Establish the full-time infection control team and intervene ICU patients with MDRO infection by using checklist for quality control management. Results: The compliance rate of all the control measures increased after intervention (P<0.05). All the indicators of quality control of hospital MDRO infection management after intervention were significant better than before (P<0.05). Conclusion: The infection control team can improve compliance of MDRO infection isolation control measures and the indicators of quality control of hospital MDRO infection management. It played an important role in MDRO infection management and should be widely used and applied.