Abstract: Objective: To explore the effect of implementing an intelligent intravenous infusion system on improving safety. Methods: A controlled clinical trial was used to compare the error rates in the process of intravenous infusion before and after implementing this intelligent system. Two wards in a certain secondary hospital in Shanghai were determined as experimental and control group and the error rate in the two wards were collected by researchers from Oct 2014 to Sep 2015. Results: After intervention, the error rate in the experimental group which implemented the intelligent intravenous infusion system significantly decreased to 0.42%, while the rate in the control group remained 4.31%. Conclusion: The intelligent intravenous infusion system could significantly reduce the error rate in the process of intravenous infusion and improve safety by rationally adjusting drop speed, and improve ways of checking and working environment.