Abstract: Objective: To assess the turnover intention of dialysis nurse specialists in Hunan province, and to identify the impact factors. Methods: Using a cluster sampling technique, 740 dialysis nurse specialists were surveyed.The Chinese version of Index of Work Satisfaction (IWS) and the Chinese version of Turnover Intention Questionnaire (TIQ) were used to collect data. The nurses' demographic data were also collected. Results: The total score of TIQ was (14.02 ± 3.30). The domain "get the possibility of external work" got the highest score, and "quit the current job possibilities" got the lowest.44 participants got high turnover intention (5.95%). The study revealed a negative relationship between job satisfaction and turnover intention (P<0.05). Turnover intention was influenced by working units, years of work experience and IWS.Conclusions: The findings suggest that turnover intention of dialysis nurse specialists is high. This study is beneficial for hospital management to increase nurses' job satisfaction and retention.