Abstract: Objective: To systematically evaluate the role of home monitoring in interstage management of infants with Hypoplastic Left Heart Syndrome or single ventricle defect. Method: Computer searched among following databases:Cochrane Library, JBI Library and the databases of Medline, EMbase, Pubmed, BIOSIS Previews, CBM, CNKI or Wanfang, and the publication language was limited to English and Chinese. Randomized controlled trial or quasiexperimental studies were used to analysis the articles. The quality of included studies was evaluated according to JBI criteria. Results: Nine quasi-experimental studies involving 1257 patients were included. The difference of weight gain during the period of palliative care was 1.64 g/day (95%CI: -1.31~4.58) between intervention group and control group and the survival odds ratio was 3.24 (95%CI: 1.64~6.42). Conclusion: Home monitoring can lead to a decrease in interstage mortality, but the impact on weight gain was not sure.