Abstract: Objective: To explore the effect of intravenous chemotherapy on the fall risk of the cancer patients. Methods: Using fall risk assessment scale of cancer patients to assess the fall risk in 343 cancer patients before chemotherapy, undergoing chemotherapy and after chemotherapy and to analyze the difference on fall risk score in three stages. Results: The distribution proportion of cancer patients which had different grade of fall risk in three stages of chemotherapy were significant different (χ2=260.753, P<0.001). The fall risk score before chemotherapy,undergoing chemotherapy and after chemotherapy were 1.08±1.93, 3.07±1.96 and 1.76±1.90 respectively, and they were statistically significant (F=92.283, P<0.001). According to the days receiving chemotherapy, we divided the patients into four different groups. And there were no significant difference of fall risk score in different groups (F=0.511, P>0.05).Conclusion: Intravenous chemotherapy could increase the fall risk in cancer patients. We should take high risk management model for the patients with intravenous chemotherapy and take measures to prevent the risk of fall before chemotherapy for increasing the work efficiency. After the patients discharged, we should also pay attention to the fall risk of the patients to ensure the patients' safety.